Synthesis Strategies

Synthesis Practice Question 1: Robinson Annulation

In this post I wanna talk about one interesting synthesis question a student brought to me. So, without a further ado, here’s the question: Propose the reasonable synthetic sequence to accomplish the following transformation— While this synthesis may look intimidating, let’s break the whole process into small steps. This will help us see how we …

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How to Convert a Trans Alkene into a Cis Alkene?

Suppose you need to accomplish the following transformation: This is not the most trivial of questions as there are no single-step reactions that can realistically accomplish this transformation. Of course, there are some isomerization techniques out there, but they all favor the more thermodynamically stable molecule. And since the more thermodynamically stable double bond is …

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