18. Synthesis of an Amine from Anisole
This is an interesting synthetic challenge as it requires us to add a long chain to an aromatic compound and assemble a functional group at the end of it.
Retrosynthetic analysis:
This synthesis uses a wide range of reactions from both first and second semester organic chemistry.
Reaction that you’ll see in this synthesis include:
- Grignard reaction
- Electrophilic aromatic substitution
- Epoxide opening
- Alcohol activation
- Substitution
- Reduction of carboxylic acid derivatives
Synthetic scheme:
