18. Synthesis of an Amine from Anisole

This is an interesting synthetic challenge as it requires us to add a long chain to an aromatic compound and assemble a functional group at the end of it.

Retrosynthetic analysis:

This synthesis uses a wide range of reactions from both first and second semester organic chemistry.

Reaction that you’ll see in this synthesis include:

  1. Grignard reaction
  2. Electrophilic aromatic substitution
  3. Epoxide opening
  4. Alcohol activation
  5. Substitution
  6. Reduction of carboxylic acid derivatives

Synthetic scheme:

Post a comment

Leave a Comment

Your email address will not be published. Required fields are marked *